Udenafil is the active ingredient in Zudena. Read everything about Udenafil and where to buy Udenafil online for ED treatment.
Udenafil was developed by the pharma company called Dong-A Pharmaceutical. It has fairly rapid onset of action (peak plasma concentration after 1 to 1.5 hours) and has long duration of action of around 11 to 13 hours. Udenafil allows once-daily dosage and typical doses are 100 and 200 mg, similar as with Viagra (sildenafil citrate).
Udenafil (sold under the brand names Zudena and Zydena) is available in Korea, Russia and the Philippines.
Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea for treatment of erectile dysfunction in November 2005 under the name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.
Investigated for treatment of erectile dysfunction and hypertension.
Mechanism Of Action
Udenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degeneration of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is produced by increased penile blood flow caused by the relaxation of penile arteries and corpus cavernosal smooth muscle. This reaction is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by udenafil reinforces erection by increasing the amount of cGMP.
The amount of time Udenafil takes to work varies from person to person, but it normally takes between half an hour and one hour. However, Udenafil may take longer to start working if you take it with a heavy meal. Its effect may last for about 3-4 hours.
Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor.
Udenafil reached maximum plasma concentrations at 0.8–1.3 h, and then declined mono-exponentially with a terminal half-life of 7.3–12.1 h in the single-dose study. The area under the time–concentration curves (AUC) and maximum plasma concentrations (Cmax) increased supraproportionally with increasing dosage in the single-dose study. During multiple dosing of udenafil, a stable state was reached at 5 days and little accumulation occurred after repeated dosing for 7 days.
Common side effects of Udenafil
- Blurred vision,
- Muscle pain,
- Flushing (sense of warmth in the face, ears, neck and trunk),
Udenafil does not affect sperm count or its health. It is a medicine that is used to treat erectile dysfunction.